CAR T Therapies: Game Changer or Culprit in Cancer Treatment?‎

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Published: Mar 5, 2024
DOI: https://doi.org/10.56512/AS.2024.1.e240305
Keywords:
CD19/BCMA targeting, , Chimeric antigen therapy, , Global collaboration, , Safety assessments, , T cell malignancy

Main Article Content

Ali Afzal
Molecular Medicine and Cancer Therapeutics Lab, Department of Zoology, Faculty of Sciences & Technology, University of Central Punjab, Lahore, Pakistan.
Muhammad Babar Khawar
Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, ‎China‎
https://orcid.org/0000-0002-1812-0591

Abstract

The FDA alerts to potential T cell malignancy risks linked to CAR T therapies targeting CD19/BCMA, recognizing their advantages but advocating vigilant monitoring. Influential factors in secondary T cell malignancy encompass viral vectors, CAR design, and patient genetics. Analytical findings highlight instances of T cell cancer, stressing the necessity for prolonged safety studies and refined CAR T strategies. Global collaboration is crucial for consistent reporting and adherence to treatments. Recommendations include extended safety assessments, refined CAR T strategies, enhanced data reporting, and global cooperation. This viewpoint addresses safety concerns regarding CAR T therapies and proposes measures to enhance their safety and effectiveness. The discussion emphasizes the importance of optimizing CAR T strategies to minimize risks and elevate treatment outcomes

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How to Cite
Afzal, A., & Khawar, M. B. (2024). CAR T Therapies: Game Changer or Culprit in Cancer Treatment?‎. Albus Scientia, 2024(1), 1–3. https://doi.org/10.56512/AS.2024.1.e240305
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Vol. 2024 No. 1 (2024): Albus Scientia
Section
Viewpoint
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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